Hi brentblue and welcome to the Q&A Forum,
The difference is in the way the card reader is connected to a computer. A reader with USB 2 compatibilty is faster than the older USB 1. The fastest connection is with Firewire (IEEE 1394 interface), but readers with this interface are not as commonly available as USB2. Companies such as Lexar, Sandisk and Delkin make CF firewire readers. Of course, you'll need a firewire port in you computer. If you have a fast memory card, that will influence the transfer rate too.
Here's an example of a Compact Flash Firewire reader:
http://www.digicamhelp.com/amazon-store/?apid=B000I6UVA0